Seeing more with less

Multi-photon microscopy: seeing more by imaging less.

Since the earliest microscopes of Leuwenhoek and Hooke in the 17th century, optical designers have strived to maximize a key performance characteristic of each new instrument model—that of contrast. Put simply, contrast is how well we can discern useful information about a microscopic specimen from unwanted background and noise. Resolution (the ability to accurately measure features) and sensit...

Systematic viewing in radiology: seeing more, missing less?

To prevent radiologists from overlooking lesions, radiology textbooks recommend "systematic viewing," a technique whereby anatomical areas are inspected in a fixed order. This would ensure complete inspection (full coverage) of the image and, in turn, improve diagnostic performance. To test this assumption, two experiments were performed. Both experiments investigated the relationship between s...

Seeing more is seeing better.

More with less Xist.

S ince the birth of Dolly, the first mammal produced from somatic cell nuclear transfer (SCNT), little progress has been made in the efficiency of cloning. Overall, about 0.5–2% of the embryos reconstructed by SCNT develop to term after transfer of reconstructed embryos to recipient females. In PNAS, Matoba et al. (1) report significant improvement in cloning efficiency by manipulation of the l...

More with Less: